Molecular and immunohistochemical expression of apoptotic proteins Bax, Bcl-2 and Caspase 3 in infantile hemangioma tissues as an effect of propranolol treatment
A Wnęk, E Andrzejewska, J Kobos, K Taran… - Immunology …, 2017 - Elsevier
Abstract Background Infantile hemangiomas (IHs) are the most common benign tumors of
childhood. They are characterized by a unique clinical course with two phases, proliferation
and involution, which are followed by regression. The therapy of infantile hemangiomas was
revolutionized in 2008 by the introduction of propranolol, however, the mechanism of its
influence on hemangiomas remains unclear. Methods The study included 71 patients with
IHs, 27 of whom were treated with propranolol while the remaining 44 were used as a …
childhood. They are characterized by a unique clinical course with two phases, proliferation
and involution, which are followed by regression. The therapy of infantile hemangiomas was
revolutionized in 2008 by the introduction of propranolol, however, the mechanism of its
influence on hemangiomas remains unclear. Methods The study included 71 patients with
IHs, 27 of whom were treated with propranolol while the remaining 44 were used as a …
