Therapeutic gold. Is it due for a come-back?
MW Whitehouse - Inflammopharmacology, 2008 - Springer
Inflammopharmacology, 2008•Springer
The historical use of metallic gold and gold complexes in medicine is briefly outlined.
Currently, there is a large body of opinion that they belong to another age, are no longer
relevant and that there are more-than-adequate successors to replace them. Nevertheless
some challenging questions remain:(1) Should we now ignore their remarkable properties
for ameliorating rheumatoid arthritis, even inducing remissions and for preventing arthritis
development in animals?(i) What mechanisms underlie their clinical activity?(ii) Can some of …
Currently, there is a large body of opinion that they belong to another age, are no longer
relevant and that there are more-than-adequate successors to replace them. Nevertheless
some challenging questions remain:(1) Should we now ignore their remarkable properties
for ameliorating rheumatoid arthritis, even inducing remissions and for preventing arthritis
development in animals?(i) What mechanisms underlie their clinical activity?(ii) Can some of …
Abstract
The historical use of metallic gold and gold complexes in medicine is briefly outlined. Currently, there is a large body of opinion that they belong to another age, are no longer relevant and that there are more-than-adequate successors to replace them. Nevertheless some challenging questions remain:
- (1) Should we now ignore their remarkable properties for ameliorating rheumatoid arthritis, even inducing remissions and for preventing arthritis development in animals?
- (i) What mechanisms underlie their clinical activity?
- (ii) Can some of the adverse effects of traditional therapy with gold-thiolate complexes be reduced/prevented by either modifying their formulations, or by using some of their bio-transformation products at much lower doses?
- (iii) Are they equivalent, perhaps even superior to biological DMARDs (anti-TNFα, anti-IL-1), and if so, more cost effective?
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