[HTML][HTML] Characterization of regulatory elements on the promoter region of p16INK4a that contribute to overexpression of p16 in senescent fibroblasts
W Wang, J Wu, Z Zhang, T Tong - Journal of Biological Chemistry, 2001 - ASBMB
Cyclin-dependent kinase inhibitor p16 INK4a is implicated in replicative senescence, cell
immortalization, and tumor generation. However, the mechanism regulating its
overexpression in senescent cells is unknown. We used the enhanced green fluorescent
protein reporter system to scan regulatory elements in the upstream region of p16 INK4a.
The results of 5′-deletion studies indicated that the transcription regulatory elements
contributing to overexpression of p16 INK4a in senescent cells were located in the region of …
immortalization, and tumor generation. However, the mechanism regulating its
overexpression in senescent cells is unknown. We used the enhanced green fluorescent
protein reporter system to scan regulatory elements in the upstream region of p16 INK4a.
The results of 5′-deletion studies indicated that the transcription regulatory elements
contributing to overexpression of p16 INK4a in senescent cells were located in the region of …