[HTML][HTML] S-palmitoylation and ubiquitination differentially regulate interferon-induced transmembrane protein 3 (IFITM3)-mediated resistance to influenza virus
The interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cellular restriction factor
that inhibits infection by influenza virus and many other pathogenic viruses. IFITM3 prevents
endocytosed virus particles from accessing the host cytoplasm although little is known
regarding its regulatory mechanisms. Here we demonstrate that IFITM3 localization to and
antiviral remodeling of endolysosomes is differentially regulated by S-palmitoylation and
lysine ubiquitination. Although S-palmitoylation enhances IFITM3 membrane affinity and …
that inhibits infection by influenza virus and many other pathogenic viruses. IFITM3 prevents
endocytosed virus particles from accessing the host cytoplasm although little is known
regarding its regulatory mechanisms. Here we demonstrate that IFITM3 localization to and
antiviral remodeling of endolysosomes is differentially regulated by S-palmitoylation and
lysine ubiquitination. Although S-palmitoylation enhances IFITM3 membrane affinity and …