[HTML][HTML] MicroRNA-92a negatively regulates Toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase
L Lai, Y Song, Y Liu, Q Chen, Q Han, W Chen… - Journal of Biological …, 2013 - ASBMB
Toll-like receptors (TLRs) play a critical role in the initiation of immune responses against
invading pathogens. MicroRNAs have been shown to be important regulators of TLR
signaling. In this study, we have found that the stimulation of multiple TLRs rapidly reduced
the levels of microRNA-92a (miRNA-92a) and some other members of the miRNA-92a
family in macrophages. miR-92a mimics significantly decreased, whereas miR-92a
knockdown increased, the activation of the JNK/c-Jun pathway and the production of …
invading pathogens. MicroRNAs have been shown to be important regulators of TLR
signaling. In this study, we have found that the stimulation of multiple TLRs rapidly reduced
the levels of microRNA-92a (miRNA-92a) and some other members of the miRNA-92a
family in macrophages. miR-92a mimics significantly decreased, whereas miR-92a
knockdown increased, the activation of the JNK/c-Jun pathway and the production of …