Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis
D Fenoglio, F Battaglia, A Parodi, S Stringara… - Clinical …, 2011 - Elsevier
Aim of the study has been to understand the relationship between TH17 and Treg cell
subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17
and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration
in the peripheral blood was found to be increased in SSc patients with respect to healthy
controls independently from type or stage of disease. After PBMC stimulation with a
polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was …
subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17
and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration
in the peripheral blood was found to be increased in SSc patients with respect to healthy
controls independently from type or stage of disease. After PBMC stimulation with a
polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was …