MicroRNA 182 inhibits CD4+ CD25+ Foxp3+ Treg differentiation in experimental autoimmune encephalomyelitis
C Wan, CY Ping, XY Shang, JT Tian, SH Zhao, L Li… - Clinical …, 2016 - Elsevier
MicroRNA 182 has been found to have a distinct contribution in the clonal expansion of
activated-and functioning of specialized-helper T cells. In this study we knocked down
microRNA 182 in vivo and induced experimental autoimmune encephalomyelitis (EAE) to
determine the influences of microRNA 182 in the Treg cells functional specialization through
Foxo1 dependent pathway in the peripheral lymphoid organs. Down-regulation of microRNA
182 significantly increased the proportions of Foxp3+ T cells in the peripheral lymph nodes …
activated-and functioning of specialized-helper T cells. In this study we knocked down
microRNA 182 in vivo and induced experimental autoimmune encephalomyelitis (EAE) to
determine the influences of microRNA 182 in the Treg cells functional specialization through
Foxo1 dependent pathway in the peripheral lymphoid organs. Down-regulation of microRNA
182 significantly increased the proportions of Foxp3+ T cells in the peripheral lymph nodes …