Expression of podocyte-associated molecules in acquired human kidney diseases

K Koop, M Eikmans, HJ Baelde… - Journal of the …, 2003 - journals.lww.com
Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies
concerning congenital nephrotic syndromes and findings in genetically modified mice have
demonstrated that podocyte molecules make a pivotal contribution to the maintenance of the
selective filtration barrier of the normal glomerulus. However, it is unclear what role podocyte
molecules play in proteinuria of acquired renal diseases. This study investigated the mRNA
and protein expression of several podocyte-associated molecules in acquired renal …