[HTML][HTML] Glycogen synthase kinase-3β (GSK3β) binds to and promotes the actions of p53
P Watcharasit, GN Bijur, L Song, J Zhu, X Chen… - Journal of Biological …, 2003 - ASBMB
The recent discovery of direct interactions between two important regulators of cell fate, the
tumor suppressor p53 and glycogen synthase kinase-3β (GSK3β), led us to examine the
mechanism and outcomes of this interaction. Two regions of p53 were identified that
regulate its binding to GSK3β. Deletion of the p53 activation domain-1 (AD1), but not
mutations that prevent MDM2 binding through the AD1 domain, enhanced GSK3β binding to
p53, indicating that the AD1 domain interferes with p53 binding to GSK3β. Deletion of the …
tumor suppressor p53 and glycogen synthase kinase-3β (GSK3β), led us to examine the
mechanism and outcomes of this interaction. Two regions of p53 were identified that
regulate its binding to GSK3β. Deletion of the p53 activation domain-1 (AD1), but not
mutations that prevent MDM2 binding through the AD1 domain, enhanced GSK3β binding to
p53, indicating that the AD1 domain interferes with p53 binding to GSK3β. Deletion of the …