Delayed administration of a single dose of lithium promotes recovery from AKI
H Bao, Y Ge, Z Wang, S Zhuang… - Journal of the …, 2014 - journals.lww.com
Evidence suggests that glycogen synthase kinase 3β (GSK3β) contributes to AKI; however,
its role in post-AKI kidney repair remains uncertain. Here, delayed treatment with a single
dose of lithium, a selective inhibitor of GSK3β and a US Food and Drug Administration–
approved mood stabilizer, accelerated recovery of renal function, promoted repopulation of
renal tubular epithelia, and improved kidney repair in murine models of cisplatin-and
ischemia/reperfusion-induced AKI. These effects associated with reduced GSK3β activity …
its role in post-AKI kidney repair remains uncertain. Here, delayed treatment with a single
dose of lithium, a selective inhibitor of GSK3β and a US Food and Drug Administration–
approved mood stabilizer, accelerated recovery of renal function, promoted repopulation of
renal tubular epithelia, and improved kidney repair in murine models of cisplatin-and
ischemia/reperfusion-induced AKI. These effects associated with reduced GSK3β activity …