[CITATION][C] Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
H Kimura, H Esumi - Acta Biochimica Polonica, 2003 - ojs.ptbioch.edu.pl
Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological
processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic
retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of
angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one
of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1)
plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide …
processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic
retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of
angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one
of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1)
plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide …