[HTML][HTML] KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling
PV DiStefano, JM Kuebel, IH Sarelius… - Journal of Biological …, 2014 - ASBMB
Disruption of endothelial cell-cell contact is a key event in many cardiovascular diseases
and a characteristic of pathologically activated vascular endothelium. The CCM (cerebral
cavernous malformation) family of proteins (KRIT1 (Krev-interaction trapped 1), PDCD10,
and CCM2) are critical regulators of endothelial cell-cell contact and vascular homeostasis.
Here we show novel regulation of vascular endothelial growth factor (VEGF) signaling in
KRIT1-depleted endothelial cells. Loss of KRIT1 and PDCD10, but not CCM2, increases …
and a characteristic of pathologically activated vascular endothelium. The CCM (cerebral
cavernous malformation) family of proteins (KRIT1 (Krev-interaction trapped 1), PDCD10,
and CCM2) are critical regulators of endothelial cell-cell contact and vascular homeostasis.
Here we show novel regulation of vascular endothelial growth factor (VEGF) signaling in
KRIT1-depleted endothelial cells. Loss of KRIT1 and PDCD10, but not CCM2, increases …