The glial identity of neural stem cells
F Doetsch - Nature neuroscience, 2003 - nature.com
F Doetsch
Nature neuroscience, 2003•nature.comGlia are the most numerous cells in the brain, and their many diverse functions highlight
their essential role in the nervous system. Recent studies have revealed an unexpected new
role for glia in a wide variety of species, that of stem cells/progenitors in the adult and
embryonic brain. Differentiation along the glial lineage may be a default state of
development reflected in the progression of stem cells along the neuroepithelial→ radial
glia→ astrocyte lineage.
their essential role in the nervous system. Recent studies have revealed an unexpected new
role for glia in a wide variety of species, that of stem cells/progenitors in the adult and
embryonic brain. Differentiation along the glial lineage may be a default state of
development reflected in the progression of stem cells along the neuroepithelial→ radial
glia→ astrocyte lineage.
Abstract
Glia are the most numerous cells in the brain, and their many diverse functions highlight their essential role in the nervous system. Recent studies have revealed an unexpected new role for glia in a wide variety of species, that of stem cells/progenitors in the adult and embryonic brain. Differentiation along the glial lineage may be a default state of development reflected in the progression of stem cells along the neuroepithelial→radial glia→astrocyte lineage.
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