Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro
L Dittmar, E Mohr, C Kleist, S Ehser, H Demirdizen… - Human immunology, 2015 - Elsevier
Previous animal studies showed that donor-derived blood cells treated with mitomycin C
(MMC) prolong allograft survival when injected into recipients. This model was effective with
whole blood, peripheral blood mononuclear cells (PBMC)(monocytes being the active cell
subpopulation) or dendritic cells. In view of a potential clinical application, we study now the
immunosuppressive properties of human myeloid cells in vitro. Mature dendritic cells
(generated from naïve monocytes) or monocytes treated with mitomycin C do not or only …
(MMC) prolong allograft survival when injected into recipients. This model was effective with
whole blood, peripheral blood mononuclear cells (PBMC)(monocytes being the active cell
subpopulation) or dendritic cells. In view of a potential clinical application, we study now the
immunosuppressive properties of human myeloid cells in vitro. Mature dendritic cells
(generated from naïve monocytes) or monocytes treated with mitomycin C do not or only …