[HTML][HTML] Effects of Peripheral Cannabinoid Receptor Ligands on Motility and Polarization in Neutrophil-like HL60 Cells and Human Neutrophils*♦
R Kurihara, Y Tohyama, S Matsusaka, H Naruse… - Journal of biological …, 2006 - ASBMB
The possible role of the peripheral cannabinoid receptor (CB2) in neutrophil migration was
investigated by using human promyelocytic HL60 cells differentiated into neutrophil-like
cells and human neutrophils isolated from whole blood. Cell surface expression of CB2 on
HL60 cells, on neutrophil-like HL60 cells, and on human neutrophils was confirmed by flow
cytometry. Upon stimulation with either of the CB2 ligands JWH015 and 2-
arachidonoylglycerol (2-AG), neutrophil-like HL60 cells rapidly extended and retracted one …
investigated by using human promyelocytic HL60 cells differentiated into neutrophil-like
cells and human neutrophils isolated from whole blood. Cell surface expression of CB2 on
HL60 cells, on neutrophil-like HL60 cells, and on human neutrophils was confirmed by flow
cytometry. Upon stimulation with either of the CB2 ligands JWH015 and 2-
arachidonoylglycerol (2-AG), neutrophil-like HL60 cells rapidly extended and retracted one …