[HTML][HTML] Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus
YP Jin, NM Valenzuela, ME Ziegler, E Rozengurt… - American Journal of …, 2014 - Elsevier
Antibody (Ab) crosslinking of HLA I molecules on the surface of endothelial cells triggers
proliferative and pro-survival intracellular signaling, which is implicated in the process of
chronic allograft rejection, also known as transplant vasculopathy (TV). The purpose of this
study was to investigate the role of mammalian target of rapamycin (mTOR) in HLA I Ab-
induced signaling cascades. Everolimus provides a tool to establish how the mTOR signal
network regulates HLA I–mediated migration, proliferation and survival. We found that …
proliferative and pro-survival intracellular signaling, which is implicated in the process of
chronic allograft rejection, also known as transplant vasculopathy (TV). The purpose of this
study was to investigate the role of mammalian target of rapamycin (mTOR) in HLA I Ab-
induced signaling cascades. Everolimus provides a tool to establish how the mTOR signal
network regulates HLA I–mediated migration, proliferation and survival. We found that …