Anti-HLA class I antibody–mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells
YP Jin, MC Fishbein, JW Said, PT Jindra… - Human immunology, 2004 - Elsevier
Anti–human leukocyte antigen (HLA) antibodies (Ab) have long been implicated in the
process of acute and chronic allograft rejection, yet their mechanism (s) of action is not well
understood. The aim of this study was to determine whether ligation of HLA class I
molecules by anti-HLA Ab on the surface of human endothelial cells (EC) activates the PI3
Kinase (PI3K)/Akt signaling pathway and downstream target proteins of the cell death
apparatus. We report that Ab ligation of major histocompatibility complex (MHC) class I …
process of acute and chronic allograft rejection, yet their mechanism (s) of action is not well
understood. The aim of this study was to determine whether ligation of HLA class I
molecules by anti-HLA Ab on the surface of human endothelial cells (EC) activates the PI3
Kinase (PI3K)/Akt signaling pathway and downstream target proteins of the cell death
apparatus. We report that Ab ligation of major histocompatibility complex (MHC) class I …