Small leucine-rich proteoglycans in kidney disease
L Schaefer - Journal of the American Society of Nephrology, 2011 - journals.lww.com
Research over the past 2 decades provides ample evidence that small leucine-rich
proteoglycans (SLRPs; such as decorin, biglycan, fibromodulin, and lumican) of the
extracellular matrix are deeply involved in the regulation of inflammatory and fibrotic renal
disorders. Initial efforts in SLRP research focused on the interaction between decorin and
TGF-β because it had been unequivocally demonstrated that decorin treatment exerts
beneficial effects in fibrotic disorders involving TGF-β overproduction in the kidney. This was …
proteoglycans (SLRPs; such as decorin, biglycan, fibromodulin, and lumican) of the
extracellular matrix are deeply involved in the regulation of inflammatory and fibrotic renal
disorders. Initial efforts in SLRP research focused on the interaction between decorin and
TGF-β because it had been unequivocally demonstrated that decorin treatment exerts
beneficial effects in fibrotic disorders involving TGF-β overproduction in the kidney. This was …