[HTML][HTML] Extracellular hmgb1 functions as an innate immune-mediator implicated in murine cardiac allograft acute rejection
Y Huang, H Yin, J Han, B Huang, J Xu, F Zheng… - American journal of …, 2007 - Elsevier
Hmgb1, an evolutionarily conserved chromosomal protein, was recently re-discovered to be
an innate immune-mediator contributing to both innate and adaptive immune responses.
Here, we show a pivotal role for Hmgb1 in acute allograft rejection in a murine cardiac
transplantation model. Extracellular Hmgb1 was found to be a potent stimulator for adaptive
immune responses. Hmgb1 can be either passively released from damaged cells after
organ harvest and ischemia/reperfusion insults, or actively secreted by allograft infiltrated …
an innate immune-mediator contributing to both innate and adaptive immune responses.
Here, we show a pivotal role for Hmgb1 in acute allograft rejection in a murine cardiac
transplantation model. Extracellular Hmgb1 was found to be a potent stimulator for adaptive
immune responses. Hmgb1 can be either passively released from damaged cells after
organ harvest and ischemia/reperfusion insults, or actively secreted by allograft infiltrated …