Myocardial lineage development
SM Evans, D Yelon, FL Conlon, ML Kirby - Circulation research, 2010 - Am Heart Assoc
SM Evans, D Yelon, FL Conlon, ML Kirby
Circulation research, 2010•Am Heart AssocThe myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized
conduction system. Specification and maturation of each of these lineages during heart
development is a highly ordered, ongoing process involving multiple signaling pathways
and their intersection with transcriptional regulatory networks. Here, we attempt to
summarize and compare much of what we know about specification and maturation of …
lineages, including those of the ventricular and atrial myocardium, and the specialized
conduction system. Specification and maturation of each of these lineages during heart
development is a highly ordered, ongoing process involving multiple signaling pathways
and their intersection with transcriptional regulatory networks. Here, we attempt to
summarize and compare much of what we know about specification and maturation of …
The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of each of these lineages during heart development is a highly ordered, ongoing process involving multiple signaling pathways and their intersection with transcriptional regulatory networks. Here, we attempt to summarize and compare much of what we know about specification and maturation of myocardial lineages from studies in several different vertebrate model systems. To date, most research has focused on early specification, and although there is still more to learn about early specification, less is known about factors that promote subsequent maturation of myocardial lineages required to build the functioning adult heart.
Am Heart Assoc