EASL clinical practice guidelines: autoimmune hepatitis
European Association for the Study of The Liver - Journal of hepatology, 2015 - Elsevier
Autoimmune hepatitis (AIH) was the first liver disease for which an effective therapeutic
intervention, corticosteroid treatment, was convincingly demonstrated in controlled clinical
trials. However, 50 years later AIH still remains a major diagnostic and therapeutic
challenge. There are two major reasons for this apparent contradiction: Firstly, AIH is a
relatively rare disease. Secondly, AIH is a very heterogeneous disease.Like other rare
diseases, clinical studies are hampered by the limited number of patients that can be …
intervention, corticosteroid treatment, was convincingly demonstrated in controlled clinical
trials. However, 50 years later AIH still remains a major diagnostic and therapeutic
challenge. There are two major reasons for this apparent contradiction: Firstly, AIH is a
relatively rare disease. Secondly, AIH is a very heterogeneous disease.Like other rare
diseases, clinical studies are hampered by the limited number of patients that can be …