RAS and RHO GTPases in G1-phase cell-cycle regulation
ML Coleman, CJ Marshall, MF Olson - Nature reviews Molecular cell …, 2004 - nature.com
ML Coleman, CJ Marshall, MF Olson
Nature reviews Molecular cell biology, 2004•nature.comAs RAS mutations are among the most frequent alterations in human cancers, RAS proteins
and their signalling pathways have been studied intensively. Here, we outline the
contributions of H-RAS, N-RAS and K-RAS to cell-cycle progression and cell growth. We
also summarize recent results that indicate how other members of the RAS-GTPase
subfamily—including E-RAS, RHEB, R-RAS, TC21 and RAL, as well as RHO GTPases—
promote proliferation by regulating the transcription, translation and degradation of key cell …
and their signalling pathways have been studied intensively. Here, we outline the
contributions of H-RAS, N-RAS and K-RAS to cell-cycle progression and cell growth. We
also summarize recent results that indicate how other members of the RAS-GTPase
subfamily—including E-RAS, RHEB, R-RAS, TC21 and RAL, as well as RHO GTPases—
promote proliferation by regulating the transcription, translation and degradation of key cell …
Abstract
As RAS mutations are among the most frequent alterations in human cancers, RAS proteins and their signalling pathways have been studied intensively. Here, we outline the contributions of H-RAS, N-RAS and K-RAS to cell-cycle progression and cell growth. We also summarize recent results that indicate how other members of the RAS-GTPase subfamily — including E-RAS, RHEB, R-RAS, TC21 and RAL, as well as RHO GTPases — promote proliferation by regulating the transcription, translation and degradation of key cell-cycle components.
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