Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
JR Smith, D Freije, JD Carpten, H Grönberg, J Xu… - Science, 1996 - science.org
Science, 1996•science.org
Despite its high prevalence, very little is known regarding genetic predisposition to prostate
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has
provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an
additional set of 25 North American and Swedish families with markers in this region
resulted in significant evidence of linkage in the combined set of 91 families. The data
provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has
provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an
additional set of 25 North American and Swedish families with markers in this region
resulted in significant evidence of linkage in the combined set of 91 families. The data
provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
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