Epigenetic factors and microRNAs (miRNAs) are regulators of gene expression. Their
regulatory function is frequently aberrant in cancer. In this chapter, we show that a tight
connection occurs between miRNAs and epigenetics. Epigenetic factors can be responsible
for the aberrancies of the miRNome (defined as the full spectrum of miRNAs for a specific
genome) observed in cancer. Indeed, miRNAs undergo the same epigenetic regulatory laws
like any other protein-coding gene. Moreover, a specific group of miRNAs (defined as epi …