[HTML][HTML] Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
MM Magaña, TF Osborne - Journal of Biological Chemistry, 1996 - ASBMB
We previously reported that sterol regulation of the rat fatty-acid synthase was lost when the
DNA sequence between− 73 and− 43 of the promoter was deleted from a luciferase reporter
construct (Bennett, MK, Lopez, JM, Sanchez, HB, and Osborne, TF (1995) J. Biol. Chem.
270, 25578-25583). We also showed that there was a binding site for sterol regulatory
element binding protein-1 (SREBP-1) in this region that contains a palindromic E-box motif
(5′-CANNTG-3′). This is the consensus recognition element for basic-helix-loop-helix …
DNA sequence between− 73 and− 43 of the promoter was deleted from a luciferase reporter
construct (Bennett, MK, Lopez, JM, Sanchez, HB, and Osborne, TF (1995) J. Biol. Chem.
270, 25578-25583). We also showed that there was a binding site for sterol regulatory
element binding protein-1 (SREBP-1) in this region that contains a palindromic E-box motif
(5′-CANNTG-3′). This is the consensus recognition element for basic-helix-loop-helix …