[HTML][HTML] Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment
AE Wentz, DA d'Avignon, ML Weber, DG Cotter… - Journal of Biological …, 2010 - ASBMB
Heart muscle is metabolically versatile, converting energy stored in fatty acids, glucose,
lactate, amino acids, and ketone bodies. Here, we use mouse models in ketotic nutritional
states (24 h of fasting and a very low carbohydrate ketogenic diet) to demonstrate that heart
muscle engages a metabolic response that limits ketone body utilization. Pathway
reconstruction from microarray data sets, gene expression analysis, protein immunoblotting,
and immunohistochemical analysis of myocardial tissue from nutritionally modified mouse …
lactate, amino acids, and ketone bodies. Here, we use mouse models in ketotic nutritional
states (24 h of fasting and a very low carbohydrate ketogenic diet) to demonstrate that heart
muscle engages a metabolic response that limits ketone body utilization. Pathway
reconstruction from microarray data sets, gene expression analysis, protein immunoblotting,
and immunohistochemical analysis of myocardial tissue from nutritionally modified mouse …