[HTML][HTML] c-Jun inhibits transforming growth factor β-mediated transcription by repressing Smad3 transcriptional activity
S Dennler, C Prunier, N Ferrand, JM Gauthier… - Journal of Biological …, 2000 - ASBMB
Transforming growth factor β (TGF-β) is a pleiotropic cytokine that exerts its effects through a
heteromeric complex of transmembrane serine/threonine kinase receptors. At least two
intracellular pathways are activated by TGF-β as follows: the SAPK/JNK, involving the
MEKK1, MKK4, and JNK cascade, and the Smad pathway. Here, we report that the
SAPK/JNK pathway inhibits the Smad3 pathway. Expression of dominant negative or
constitutively active mutants of kinases of the SAPK/JNK pathway, respectively, activates or …
heteromeric complex of transmembrane serine/threonine kinase receptors. At least two
intracellular pathways are activated by TGF-β as follows: the SAPK/JNK, involving the
MEKK1, MKK4, and JNK cascade, and the Smad pathway. Here, we report that the
SAPK/JNK pathway inhibits the Smad3 pathway. Expression of dominant negative or
constitutively active mutants of kinases of the SAPK/JNK pathway, respectively, activates or …
