[HTML][HTML] Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways
T Ueda, N Bruchovsky, MD Sadar - Journal of Biological Chemistry, 2002 - ASBMB
The androgen receptor (AR) is a ligand-activated transcription factor that mediates the
biological responses of androgens. However, non-androgenic pathways have also been
shown to activate the AR. The mechanism of cross-talk between the interleukin-6 (IL-6) and
AR signal transduction pathways was investigated in LNCaP human prostate cancer cells. IL-
6 induced several androgen-response element-driven reporters that are dependent upon
the AR, increased the phosphorylation of mitogen-activated protein kinase (MAPK), and …
biological responses of androgens. However, non-androgenic pathways have also been
shown to activate the AR. The mechanism of cross-talk between the interleukin-6 (IL-6) and
AR signal transduction pathways was investigated in LNCaP human prostate cancer cells. IL-
6 induced several androgen-response element-driven reporters that are dependent upon
the AR, increased the phosphorylation of mitogen-activated protein kinase (MAPK), and …