The biology of influenza viruses

NM Bouvier, P Palese - Vaccine, 2008 - Elsevier
NM Bouvier, P Palese
Vaccine, 2008Elsevier
The influenza viruses are characterized by segmented, negative-strand RNA genomes
requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular
structure of the influenza virus genome and function of its viral proteins enable antigenic drift
and antigenic shift. These processes result in viruses able to evade the long-term adaptive
immune responses in many hosts.
The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins enable antigenic drift and antigenic shift. These processes result in viruses able to evade the long-term adaptive immune responses in many hosts.
Elsevier