Role of myocardial catecholamines in cardiac contractility

WC Lee, FE Shideman - Science, 1959 - science.org
WC Lee, FE Shideman
Science, 1959science.org
In cats bilateral sympathectomy or administration of reserpine results in a marked reduction
in concentration of myocardial catecholamines. The contractility of papillary muscles from
such animals is significantly less than that of muscles from untreated animals. These
findings demonstrate the importance of normal levels of myocardial catecholamines in the
maintenance of normal cardiac contractility.
In cats bilateral sympathectomy or administration of reserpine results in a marked reduction in concentration of myocardial catecholamines. The contractility of papillary muscles from such animals is significantly less than that of muscles from untreated animals. These findings demonstrate the importance of normal levels of myocardial catecholamines in the maintenance of normal cardiac contractility.
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