The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis
X Sun, M Minohara, H Kikuchi, T Ishizu… - Journal of …, 2006 - Elsevier
We studied the role of fasudil, a selective Rho-kinase inhibitor, in experimental autoimmune
encephalomyelitis (EAE). Both parenteral and oral administration of fasudil prevented the
development of EAE induced by proteolipid protein (PLP) p139-151 in SJL/J mice. Specific
proliferation of lymphocytes to PLP was significantly reduced, together with a
downregulation of interleukin (IL)-17 and a marked decrease of the IFN-γ/IL-4 ratio.
Immunohistochemical examination also disclosed a marked decrease of inflammatory cell …
encephalomyelitis (EAE). Both parenteral and oral administration of fasudil prevented the
development of EAE induced by proteolipid protein (PLP) p139-151 in SJL/J mice. Specific
proliferation of lymphocytes to PLP was significantly reduced, together with a
downregulation of interleukin (IL)-17 and a marked decrease of the IFN-γ/IL-4 ratio.
Immunohistochemical examination also disclosed a marked decrease of inflammatory cell …
