[HTML][HTML] General transcription factor IIA-γ increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription …
S Yu, Y Jiang, DL Galson, M Luo, Y Lai, Y Lu… - Journal of biological …, 2008 - ASBMB
ATF4 (activating transcription factor 4) is an osteoblast-enriched transcription factor that
regulates terminal osteoblast differentiation and bone formation. ATF4 knock-out mice have
reduced bone mass (severe osteoporosis) throughout life. Runx2 (runt-related transcription
factor 2) is a runt domain-containing transcription factor that is essential for bone formation
during embryogenesis and postnatal life. In this study, we identified general transcription
factor IIAγ (TFIIAγ) as a Runx2-interacting factor in a yeast two-hybrid screen …
regulates terminal osteoblast differentiation and bone formation. ATF4 knock-out mice have
reduced bone mass (severe osteoporosis) throughout life. Runx2 (runt-related transcription
factor 2) is a runt domain-containing transcription factor that is essential for bone formation
during embryogenesis and postnatal life. In this study, we identified general transcription
factor IIAγ (TFIIAγ) as a Runx2-interacting factor in a yeast two-hybrid screen …