[HTML][HTML] Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression
G Xiao, D Jiang, C Ge, Z Zhao, Y Lai, H Boules… - Journal of Biological …, 2005 - ASBMB
The role of ATF4 (activating transcription factor 4) in osteoblast differentiation and bone
formation was recently described using ATF4-deficient mice (Yang, X., Matsuda, K., Bialek,
P., Jacquot, S., Masuoka, HC, Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes,
TM, Hanauer, A., and Karsenty, G.(2004) Cell 117, 387–398). However, the mechanisms of
ATF4 in bone cells are still not clear. In this study, we determined the molecular mechanisms
through which ATF4 activates the mouse osteocalcin (Ocn) gene 2 (mOG2) expression and …
formation was recently described using ATF4-deficient mice (Yang, X., Matsuda, K., Bialek,
P., Jacquot, S., Masuoka, HC, Schinke, T., Li, L., Brancorsini, S., Sassone-Corsi, P., Townes,
TM, Hanauer, A., and Karsenty, G.(2004) Cell 117, 387–398). However, the mechanisms of
ATF4 in bone cells are still not clear. In this study, we determined the molecular mechanisms
through which ATF4 activates the mouse osteocalcin (Ocn) gene 2 (mOG2) expression and …