[HTML][HTML] Processing of transforming growth factor β1 precursor by human furin convertase
CM Dubois, MH Laprise, F Blanchette, LE Gentry… - Journal of Biological …, 1995 - ASBMB
Proteolytic processing of the transforming growth factor β precursor (pro-TGFβ) is an
essential step in the formation of the biologically active TGFβ homodimeric protein (TGFβ).
The 361-amino-acid precursor pro-TGFβ1 has within its primary structure the RHRR
processing signal found in many constitutively secreted precursor proteins and potentially
recognized by members of the mammalian convertase family of endoproteases. To
determine whether cleavage of pro-TGFβ1 can be achieved by the furin convertase in vitro …
essential step in the formation of the biologically active TGFβ homodimeric protein (TGFβ).
The 361-amino-acid precursor pro-TGFβ1 has within its primary structure the RHRR
processing signal found in many constitutively secreted precursor proteins and potentially
recognized by members of the mammalian convertase family of endoproteases. To
determine whether cleavage of pro-TGFβ1 can be achieved by the furin convertase in vitro …