Actin ring formation is a prerequisite for osteoclast bone resorption. Although gelsolin null
osteoclasts failed to exhibit podosomes, actin ring was observed in these osteoclasts.
Wiscott-Aldrich syndrome protein (WASP) was observed in the actin ring of gelsolin null
osteoclast. Osteoclasts stimulated with osteopontin simulated the effects of Rho and Cdc42
in phosphatidylinositol 4, 5-bisphosphate (PIP 2) association with WASP as well as
formation of podosomes, peripheral microfilopodia-like structures, and actin ring. To explore …