Multiple roles for Cdc42 in cell regulation
JW Erickson, RA Cerione - Current opinion in cell biology, 2001 - Elsevier
JW Erickson, RA Cerione
Current opinion in cell biology, 2001•ElsevierThe Rho family member Cdc42 can signal through a number of cellular pathways
fundamental to growth, differentiation and apoptosis. Recently, information has come at an
impressive pace, both with regard to previously identified targets for Cdc42 that regulate the
actin cytoskeleton (eg WASP) and cellular stress pathways (eg PAK) and with regard to
newly identified targets such as the coatomer protein complex and PAR6. Recent results hint
at a previously unappreciated link between these various cellular processes.
fundamental to growth, differentiation and apoptosis. Recently, information has come at an
impressive pace, both with regard to previously identified targets for Cdc42 that regulate the
actin cytoskeleton (eg WASP) and cellular stress pathways (eg PAK) and with regard to
newly identified targets such as the coatomer protein complex and PAR6. Recent results hint
at a previously unappreciated link between these various cellular processes.
The Rho family member Cdc42 can signal through a number of cellular pathways fundamental to growth, differentiation and apoptosis. Recently, information has come at an impressive pace, both with regard to previously identified targets for Cdc42 that regulate the actin cytoskeleton (e.g. WASP) and cellular stress pathways (e.g. PAK) and with regard to newly identified targets such as the coatomer protein complex and PAR6. Recent results hint at a previously unappreciated link between these various cellular processes.
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