[HTML][HTML] Dual oncostatin M (OSM) receptors: cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
B Mosley, C De Imus, D Friend, N Boiani… - Journal of Biological …, 1996 - ASBMB
Oncostatin M (OSM) is a cytokine whose structural and functional features are similar to
other members of the interleukin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory
factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and
cardiotrophin-1), many of which utilize gp130 as a common receptor subunit. A biologically
active OSM receptor has been previously described that consists of a heterodimer of
leukemia inhibitory factor receptor (LIFR) and gp130. This LIFR· gp130 complex is also a …
other members of the interleukin (IL)-6 family of cytokines (IL-6, IL-11, leukemia inhibitory
factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and
cardiotrophin-1), many of which utilize gp130 as a common receptor subunit. A biologically
active OSM receptor has been previously described that consists of a heterodimer of
leukemia inhibitory factor receptor (LIFR) and gp130. This LIFR· gp130 complex is also a …