Bone morphogenetic protein 24 in early fibromatous lesions of fibrodysplasia ossificans progressiva
FH Gannon, FS Kaplan, E Olmsted, GC Finkel… - Human pathology, 1997 - Elsevier
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by
congenital malformation of the great toes and progressive heterotopic ossification in distinct
anatomic patterns. Early preosseous lesions in FOP are clinically and histologically
indistinguishable from the lesions of aggressive juvenile fibromatosis (AJF). Although the
genetic defect in FOP is unknown, bone morphogenetic proteins (BMPs) 2 and 4 are
plausible candidates genes. To determine if there is a difference in BMP 2 4 expression in …
congenital malformation of the great toes and progressive heterotopic ossification in distinct
anatomic patterns. Early preosseous lesions in FOP are clinically and histologically
indistinguishable from the lesions of aggressive juvenile fibromatosis (AJF). Although the
genetic defect in FOP is unknown, bone morphogenetic proteins (BMPs) 2 and 4 are
plausible candidates genes. To determine if there is a difference in BMP 2 4 expression in …