[HTML][HTML] A novel receptor activator of NF-κB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast …
D Xu, S Wang, W Liu, J Liu, X Feng - Journal of Biological Chemistry, 2006 - ASBMB
Receptor activator of NF-κB (RANK) ligand (RANKL) and its receptor RANK play an
essential role in osteoclastogenesis and osteoclast function by activating several signaling
pathways. However, several lines of evidence suggest that RANK also transmits an
unidentified signaling pathway (s) essential for osteoclastogenesis. To identify the novel
pathway (s), we carried out a detailed structure/function study of the RANK cytoplasmic
domain. A series of studies using numerous deletion/point mutants elucidated a specific 4 …
essential role in osteoclastogenesis and osteoclast function by activating several signaling
pathways. However, several lines of evidence suggest that RANK also transmits an
unidentified signaling pathway (s) essential for osteoclastogenesis. To identify the novel
pathway (s), we carried out a detailed structure/function study of the RANK cytoplasmic
domain. A series of studies using numerous deletion/point mutants elucidated a specific 4 …