[HTML][HTML] Cloning and functional characterization of novel large conductance calcium-activated potassium channel β subunits, hKCNMB3 and hKCNMB4
R Brenner, TJ Jegla, A Wickenden, Y Liu… - Journal of Biological …, 2000 - ASBMB
We present the cloning and characterization of two novel calcium-activated potassium
channel β subunits, hKCNMB3 and hKCNMB4, that are enriched in the testis and brain,
respectively. We compare and contrast the steady state and kinetic properties of these β
subunits with the previously cloned mouse β1 (mKCNMB1) and the human β2 subunit
(hKCNMB2). Once inactivation is removed, we find that hKCNMB2 has properties similar to
mKCNMB1. hKCNMB2 slowsHslo1 channel gating and shifts the current-voltage …
channel β subunits, hKCNMB3 and hKCNMB4, that are enriched in the testis and brain,
respectively. We compare and contrast the steady state and kinetic properties of these β
subunits with the previously cloned mouse β1 (mKCNMB1) and the human β2 subunit
(hKCNMB2). Once inactivation is removed, we find that hKCNMB2 has properties similar to
mKCNMB1. hKCNMB2 slowsHslo1 channel gating and shifts the current-voltage …
