The BK channel β1 subunit gene is associated with human baroreflex and blood pressure regulation
M Gollasch, J Tank, FC Luft, J Jordan… - Journal of …, 2002 - journals.lww.com
Journal of hypertension, 2002•journals.lww.com
Background The baroreflex, which is important for the minute-to-minute regulation of blood
pressure and heart rate, is influenced by genetic variance. Ion channels are important to
baroreflex afferent and efferent function. Mice missing the β1 subunit of the Ca 2+-sensitive
potassium channel (BK) are hypertensive and have a reset baroreflex. We tested the
hypothesis that variants in the gene (KCNMB1) coding for the BK β1 subunit are associated
with baroreflex function. Methods
pressure and heart rate, is influenced by genetic variance. Ion channels are important to
baroreflex afferent and efferent function. Mice missing the β1 subunit of the Ca 2+-sensitive
potassium channel (BK) are hypertensive and have a reset baroreflex. We tested the
hypothesis that variants in the gene (KCNMB1) coding for the BK β1 subunit are associated
with baroreflex function. Methods
Abstract
Background
The baroreflex, which is important for the minute-to-minute regulation of blood pressure and heart rate, is influenced by genetic variance. Ion channels are important to baroreflex afferent and efferent function. Mice missing the β1 subunit of the Ca 2+-sensitive potassium channel (BK) are hypertensive and have a reset baroreflex. We tested the hypothesis that variants in the gene (KCNMB1) coding for the BK β1 subunit are associated with baroreflex function.
Methods
Lippincott Williams & Wilkins